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Home https://server7.kproxy.com/servlet/redirect.srv/sruj/smyrwpoii/p2/ Health https://server7.kproxy.com/servlet/redirect.srv/sruj/smyrwpoii/p2/ New gene examinations for germs rapidly reveal sources of infections

New gene examinations for germs rapidly reveal sources of infections



Brian Jetter is in the life support, a healthy 40-year-old who suddenly fought pneumonia and sepsis, and a very small test did not get the reason.

These mysterious diseases kill thousands of people each year when germs can not be identified quickly enough to show proper treatment. Now genetic tests help to solve these cases.

One finally used to find the blood of Jetter for pieces of non-human genetic material from viruses, fungi and so on. It discovered unusual bacteria that were likely to be acquired by the lungs of Connecticut when he was induced and unintentionally overwhelmed bits of burgers a week earlier.

With the right medication, he got home and went home with his 5-year-old son.

"I realize how hard life is," says Jetter. "No matter how healthy you are, the smallest germ can kill you."

Doctors regularly use genetic tests to detect inherited diseases and cancer treatment guidelines. But using them to detect infectious diseases is very large that some doctors and even fewer patients know this is available. A study of a test was published in the New England Journal of Medicine on Thursday.

Changing the field of long overdue for a careful review.

In order to identify the bacteria, laboratories are still expecting the techniques of the century from Louis Pasteur some drops of blood or other lab samples in the lab and waiting days or sometimes weeks to see what germs grow. To test a virus, the doctor often predicts what the patient is. The test for a fungus or some other item may take a long time.

Many companies and university labs now offer tests based on blood genes or spinal fluid. When found fragments of foreign DNA or other genetic material, their code is evaluated, or followed, to identify bacteria, viruses, fungi and parasites causing sepsis, meningitis, encephalitis and other deadly disease. it can search all at once "rather than making separate tests for every virus or other microbe that is suspected, Dr. Charles Chiu, a microbiologist at the University of California, San Francisco said.

Headed he studied the New England Journal to test a fluid test in 204 children and adults with meningitis or encephalitis, a dangerous illness that was not always caused by infection.

Gene testing was not perfect. cases, but others also found that the usual tests were passed.

Of all, 58 infections were evaluated. The gene examinations correspond to standard lab tests in 1

9 cases, it has seen 13 more than one standard diagnosis has been missed, and it has been over 26 in which the usual tests have been found at the end.

Doctors say that gen-based tests may be a quick, non-invasive first step For serious or unusual cases.

"For infectious diseases, you need to know the answer today," because the risk of a patient dying is that the cause has not been found, said Dr Asim Ahmed, medical director at Karius Inc.

The Redwood City, California company, is selling blood tests developed by Stanford University scientists seeking 1,200 bacteria, fungi, viruses and parasites simultaneously and yielded results within two days . The test presented a high standard lab treaty agreement in a study on the journal Nature Microbiology.

"The biggest issue is the cost" – around $ 2,000 for Karius testing, said Ali Torkamani, a San Diego scientist who manages a genetics conference that featured these tests in March. More competition could lower prices and lead to greater use, he said.

Karius has its own lab for testing. Other companies offer software and tools that hospitals can use to develop their own gene based tests. One of these, Arc Bio, based in California and Massachusetts, offers blood blood tests and provides answers for less than two days.

IDBDDNA, based in San Francisco, uses a Utah lab working on 3,000 US hospitals. It provides an answer for about 48 hours when a sample arrives, said the chief medical officer, Dr. Robert Schlaberg, a pathologist at the University of Utah.

Hospitals today use these tests for the worst cases – long, ill-defined ill or poor patients such as children and people with cancer or poor immune system.

Dr. Asha Shah tested the first time last year, when Jetter quickly appeared at Stamford Hospital in Connecticut.

"He had many blood tests, chest X-rays, CAT scans, you name it," he said. "I thought, this is not reasonable, why do not we get any answers?"

Karius's examinations revealed unusual oral bacteria in her lungs, indicating that she wanted the breathing of the couple while listening to the burgers.

A more unusual story appeared when Dr. Amir Khan, a specialist in the Carle Foundation Hospital in Urbana, Illinois, ordered a Karius exam for 47-year-old Ryan Springer, first suspected with cancer.

The feeling of breathing is the feeling of my lungs being fired, "says Springer, a director of the radio station program in Champaign, Illinois.

He was upset with tularemia, sometimes called" rabbit fever, "which may have come from inhaling bacteria from infections of rodents or running their stools in a lawn mower. With proper treatment, he got it."

"This is the future of medicine," Khan said. patients are sick, "every minute and hour counts."

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Marilynn Marchione may comply with http://twitter.com/MMarchioneAP .

___ [19659002] The Associated Press Health and Science Department receives support from the Howard Hughes Medical Institute's Department of Science Education. The AP is solely responsible for all content.


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