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Scientists Make the World's First 3D-Printed Heart Using a Patient's Own Cell



Researchers at Tel Aviv University were successfully printed in the first 3D heart of the world using a patient's own cells and biological patients "fully compatible with immunological, cellular, biochemical, and anatomical patients of the patient. "

Until now, "This heart is made from human cells and biological material patients. In our process, these materials serve as bioinks, substances produced by sugars and proteins that can be used for 3D printing complex tissue models, "noted leading researcher Tal Dvir in a statement. "People have managed 3D print structure of a heart in the past, but not in cells or in blood vessels. Our results show the potential of our technique for engineering personalized tissue and organs in exchange for future. "

F, G) A printed heart within a bath of support. H) After extraction, the left and right ventricles are injected with red and blue dyes, respectively, to show the hollow chambers and the septum between them. Advanced Science

Describes their work in Advanced Science, the research team has begun by taking biopsy of fatty tissues from stomach structures known as omentum to both people and pigs. Cellular tissue tissue is separated from non-reprogrammed cells to become pluripotent stem cells, "master cells" that produce cells from all three layers of the body that have the potential to make any cell or tissue in the body. The group then created the extracellular matrix – composed of collagen and glycoprotein – in a hydrogel used as "ink" in the printing. The cells are mixed with hydrogel and then vary in the heart or endothelial cells (those lined up in the inner surface of the blood and the lymphatic vessels) to create a specific patient, immune-compatible cardiac patches complete with blood vessels and, ultimately, a whole bioengineered heart

Although promising, the team will quickly remind us that their hearts are not ready for human transplantation.

"At this stage, our 3D heart is small, the size of the heart of a rabbit," says Dvir. "But the bigger human heart needs the same technology."

For beginners, creating a human heart is much longer and requires billions of cells – not just millions. Furthermore, cherry-size hearts do not necessarily act like hearts, which require researchers to further develop and "train them" to be like human hearts and to develop an ability to pumping. Currently, cells can be contracted but not working together.

Regardless, development is a huge step for the development of organ transplantation. Heart disease is the leading cause of death among men and women in the US, with heart transplants being the only treatment available to those with heart failure. Not only does the lack of donors require the development of new strategies, but the creation of hearts entertaining the unique biological makeup of a patient can prevent the risk of rejection.

"The biocompatibility of engineered materials is important to eliminate the risk of pushing the decline, damaging the success of such treatment," says Dvir. "Ideally, biomaterials should have both biochemical, mechanical and topographical properties of the patient's own tissues. Here, we can report a simple approach to 3D-printed thick, vascularized and perfusable cardiac tissues completely matching the patient's immunological, cellular, biochemical and anatomical properties. "

After the" practice "of the hearts to pump well, the team hopes to plant them in animals for further testing.

Cells from the patient's tissue of the omentum are separated and processed into a personalized thermoresponsive hydrogel. Cells are reprogrammed to become pluripotent and then vary in cardiomyocytes and endothelial cells before encapsulation within the hydrogel to produce bioinks used for printing. The bioinks are then printed on engineer vascularized patches and complex cellularized structures. Advanced Science

                                    


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