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Better biosensor technology created for stem cells



  Better biosensor technology created for stem cells
This unique biosensing platform consists of a set of ultrathin graphene layers and gold nanostructures. The platform, combined with high-tech imaging (Raman spectroscopy), detects genetic material (RNA) and identifies different types of stem cells with greater reliability, compatibility and sensitivity than in biosensors today. Credit: Letao Yang, KiBum Lee, Jin-Ho Lee and Sy-Tsong (Dean) Chueng

A team led by Rutgers has created better biosensor technology that can help lead to safe stem cell therapy for treating Alzheimer's disease and Parkinson's and other diseases in the neurological.


The technology, which features a unique graphene and gold-based platform and high-tech imaging, monitors the fate of stem cells by removing the genetic material (RNA) involved in making such cells in brain cells (neurons), according to a study in the journal Nano Letters .

Stem cells can be many different types of cells. As a result, stem cell therapy demonstrates promise for regenerative treatment of neurological diseases such as Alzheimer's, Parkinson's, stroke and spinal cord injury, with diseased cells requiring replacement or repair. But identifying stem cells and controlling their fate must be resolved before they can be used in treatment. The formation of tumors and uncontrolled transformation of stem cells remain major obstacles.

"A critical challenge is ensuring high sensitivity and accuracy in the removal of biomarkers ̵

1; indicators such as modified genes or proteins – within the complex stem cell microenvironment," says the senior author KiBum Lee, a professor in the Department of Chemistry and Chemical Biology at the School of Arts and Sciences at Rutgers University-New Brunswick. "Our technology, which took four years to develop, has shown great potential for the evaluation of different interactions with stem cells."

The team's unique biosensing platform consists of a set of ultrathin graphene layers and gold nanostructures. The platform, combined with high-tech imaging (Raman spectroscopy), detects genes and identifies different types of stem cells with greater reliability, sequence and sensitivity than the biosensors today.

The team believes that technology can benefit a range of applications. By developing simple, fast and accurate sensing platforms, Lee's group aims to facilitate the treatment of neurological disorders through stem cell therapy.

Stem cells can be a renewable source of replacement cells and tissues to treat diseases including macular degeneration, spinal cord injury, stroke, burns, heart disease, diabetes, osteoarthritis and rheumatoid arthritis, according to at the National Institutes of Health.


New nanotechnology may aid in cell-cell transplantation research


More info:
Letao Yang et al, Dual-Enhanced Raman Scattering-Based Characterization of Stem Cell Comparison Using Graphene-Plasmonic Hybrid Nanoarray, Nano Letter (2019). DOI: 10.1021 / acs.nanolett.9b03402

Issued by
Rutgers University

Citations :
Better biosensor technology created for stem cells (2019, November 11)
acquired on November 11, 2019
from https://phys.org/news/2019-11-biosensor-technology-stem-cells.html

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